Aryl Hydrocarbon Receptor Connects Inflammation to Breast Cancer

The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a battery of genes in response to exposure to a broad class of environmental poly aromatic hydrocarbons (PAH). AhR is historically characterized for its role in mediating the toxicity and adaptive responses to these chemicals, however mounting evidence has established a role for it in ligand-independen...

Aryl hydrocarbon receptor and lung cancer.

The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important ste...

Aryl Hydrocarbon Receptor Activation

Novel Aryl Hydrocarbon Receptor Agonist Suppresses Migration and Invasion of Breast Cancer Cells

BACKGROUND Despite the remarkable progress to fight against breast cancer, metastasis remains the dominant cause of treatment failure and recurrence. Therefore, control of invasiveness potential of breast cancer cells is crucial. Accumulating evidences suggest Aryl hydrocarbon receptor (Ahr), a helix-loop-helix transcription factor, as a promising target to control migration and invasion in bre...

Chemosensitization of Resistant Breast and Prostate Cancer Cells by Selective Aryl Hydrocarbon Receptor Modulators (sahrms)

Recent reports indicate that SAhRMs such as 3, 3’-diindolylmethane (DIM) inhibit α-estrogen receptor (ER) expression and estrogen signaling in human breast cancer cells and inhibit androgen receptor (AR) signaling in human prostate cancer cells. DIM is an AhR agonist derived from Brassica vegetables and has been shown to have antiproliferative and proapoptotic effects in breast and prostate can...